8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one
G-749
CAS: 1457983-28-6
Molecular Formula: C25H25BrN6O2
8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one - Names and Identifiers
8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one - Physico-chemical Properties
| Molecular Formula | C25H25BrN6O2 |
| Molar Mass | 521.41 |
| Density | 1.487±0.06 g/cm3(Predicted) |
| Solubility | DMSO: 25 mg/mL |
| pKa | 8.32±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | RS4-11 potently inhibited FLT3 autophosphorylation with an IC50 of <8 nM in FLT3-WT of the MV4-11 cell load and Molm-14 of the FLT3-ITD containing G-749 and cells. In leukemic cells, G-749 showed antiproliferative activity by inducing apoptosis. In BaF3 cell lines stably expressing FLT3-ITD/N676D,FLT3-ITD/F691L,FLT3-D835Y, or FLT3-D835Y/N676D, G-749 showed strong inhibitory activity with IC50 <10 nM, thereby overcoming drug resistance. Of the blast cells in AML patients, G-749 also showed potent anti-leukemic effects. |
| In vivo study | G-749 (30 mg/kg p.o.) potently inhibited the FLT3 pathway and significantly inhibited tumor growth in MV4-11 xenografted mice. In an orthogonal model using Molm-14 cell bone marrow transplantation, G-749 (20 mg/kg p.o.) also inhibited tumor growth and improved survival. |
8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.918 ml | 9.589 ml | 19.179 ml |
| 5 mM | 0.384 ml | 1.918 ml | 3.836 ml |
| 10 mM | 0.192 ml | 0.959 ml | 1.918 ml |
| 5 mM | 0.038 ml | 0.192 ml | 0.384 ml |
Last Update：2024-01-02 23:10:35
8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one - Introduction
G-749 is a chemical, also known as polyfluorosilane. It is a colorless liquid with low surface tension and Good wettability. This compound is unstable at high temperatures and decomposes. G-749 are mainly used in the preparation of optical fiber coatings and optical materials, as surfactants, waterproofing agents and oil repellents. It can make the coating form a uniform and transparent protective layer on the fiber and improve the efficiency of optical transmission.
The preparation method of G-749 is generally synthesized by chemical reaction. The specific preparation method may involve various steps, such as silanization reaction, fluorination reaction, etc. The details of specific preparations may require reference to specialized chemical literature or experimental protocols.
Regarding the safety information of G-749, first of all, it is necessary to pay attention to the toxicity of the compound to the human body. Contact or inhalation of its vapor or solution may affect health. Therefore, when using the G-749, you should follow the safety procedures and take appropriate protective measures, such as wearing chemical protective gloves, goggles and protective clothing. In addition, G-749 also has a high volatility, so it is necessary to maintain good ventilation during operation to avoid its vapor accumulation. When G-749 waste is disposed of, it should be disposed of in accordance with local waste disposal regulations. It is best to refer to the Safety Data Sheet or related guidelines for detailed G-749 safety information.
The preparation method of G-749 is generally synthesized by chemical reaction. The specific preparation method may involve various steps, such as silanization reaction, fluorination reaction, etc. The details of specific preparations may require reference to specialized chemical literature or experimental protocols.
Regarding the safety information of G-749, first of all, it is necessary to pay attention to the toxicity of the compound to the human body. Contact or inhalation of its vapor or solution may affect health. Therefore, when using the G-749, you should follow the safety procedures and take appropriate protective measures, such as wearing chemical protective gloves, goggles and protective clothing. In addition, G-749 also has a high volatility, so it is necessary to maintain good ventilation during operation to avoid its vapor accumulation. When G-749 waste is disposed of, it should be disposed of in accordance with local waste disposal regulations. It is best to refer to the Safety Data Sheet or related guidelines for detailed G-749 safety information.
Last Update：2024-04-09 21:31:56
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Spot supply
Product Name: G-749 Visit Supplier Webpage Request for quotationCAS: 1457983-28-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one